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John K Fink Selected Research

neurotoxic esterase

1/2020Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN).
2/2015Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.
1/2011Motor neuron disease due to neuropathy target esterase gene mutation: clinical features of the index families.
11/2010Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.
7/2010Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.
3/2008Neuropathy target esterase gene mutations cause motor neuron disease.

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John K Fink Research Topics

Disease

4Motor Neuron Disease (Primary Lateral Sclerosis)
01/2011 - 03/2008
3Hepatolenticular Degeneration (Wilson's Disease)
08/2009 - 03/2003
3Neurologic Manifestations (Neurological Manifestations)
04/2006 - 03/2003
3Hereditary Spastic Paraplegia
03/2006 - 06/2004
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2020 - 09/2005
2autosomal dominant Spastic paraplegia 3
09/2013 - 03/2006
2Pancytopenia
11/2009 - 09/2003
1Laurence-Moon Syndrome (Syndrome, Laurence-Moon)
02/2015
1Paraplegia (Spastic Paraplegia)
09/2013
1Adducted Thumbs) Syndrome Shuffling Gait Aphasia MASA (Mental Retardation
09/2013
1autosomal dominant Spastic paraplegia 6
09/2013
1Paralysis (Palsy)
03/2013
1Diabetic Neuropathies (Diabetic Neuropathy)
03/2013
1Movement Disorders (Movement Disorder)
06/2011
1Dystonia (Limb Dystonia)
06/2011
1Autosomal Recessive Spastic Paraplegia 39
07/2010
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
03/2008
1Leukopenia
04/2006
1Anemia
04/2006
1Muscle Spasticity (Spastic)
01/2006
1Cerebrotendinous Xanthomatosis
09/2005
1Cardiomyopathies (Cardiomyopathy)
10/2004
1Myosin Storage Myopathy
10/2004
1Hepatic Porphyrias (Hepatic Porphyria)
10/2004
1Distal Myopathies (Distal Muscular Dystrophy)
10/2004
1Nervous System Diseases (Neurological Disorders)
07/2004
1Dyskinesias (Dyskinesia)
07/2004
1Paroxysmal nonkinesigenic dyskinesia
07/2004
1X-Linked Mental Retardation (Mental Retardation, X Linked)
01/2002
1Intellectual Disability (Idiocy)
01/2002
1Epilepsy (Aura)
01/2002

Drug/Important Bio-Agent (IBA)

6neurotoxic esteraseIBA
01/2020 - 03/2008
3Proteins (Proteins, Gene)FDA Link
09/2013 - 03/2006
3ZincIBA
11/2009 - 03/2003
3CopperIBA
11/2009 - 09/2003
3tetrathiomolybdate (ammonium tetrathiomolybdate)IBA
08/2009 - 03/2003
2SpastinIBA
09/2013 - 06/2004
2Trientine (Trien)FDA Link
08/2009 - 04/2006
2Pharmaceutical PreparationsIBA
04/2006 - 03/2003
1connexin 47IBA
09/2013
1Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)IBA
09/2013
1Phospholipids (Phosphatides)FDA LinkGeneric
09/2013
1Fatty Acids (Saturated Fatty Acids)IBA
09/2013
1EstersIBA
03/2013
1Neurotransmitter Agents (Neurotransmitter)IBA
06/2011
1Dihydroxyphenylalanine (Dopa)IBA
06/2011
1Dopamine (Intropin)FDA LinkGeneric
06/2011
1Levodopa (L Dopa)FDA LinkGeneric
06/2011
1EnzymesIBA
11/2010
1EsterasesIBA
07/2010
1Ceruloplasmin (Ferroxidase)IBA
08/2009
1Aryldialkylphosphatase (Paraoxonase)IBA
03/2008
1Transaminases (Aminotransferases)IBA
04/2006
1DNA (Deoxyribonucleic Acid)IBA
03/2006
1ElementsIBA
01/2006
1Mixed Function Oxygenases (Monooxygenases)IBA
09/2005
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
10/2004
1MetalloporphyrinsIBA
10/2004
1heme aIBA
10/2004
1PorphyrinsIBA
10/2004
1Ion Channels (Ion Channel)IBA
07/2004
1Caffeine (No Doz)FDA LinkGeneric
07/2004
1Penicillamine (Cuprimine)FDA Link
03/2003
1TetraspaninsIBA
01/2002

Therapy/Procedure

1Physical Therapy Modalities (Physical Therapy Technique)
01/2006
1Therapeutics
03/2003